Victor W. RodwellProfessor Emeritus I retired from the Biochemistry faculty in 2004, and thus no longer accept students or visitors. |
 |
As an Emeritus Professor, I continue to collaborate with Prof. Cynthia Stauffacher of Purdue's Department of Biological Sciences, with investigators at Southern Research Institute in Birmingham, Alabama, and with Prof. Autumn Sutherlin of the Department of Chemistry at Abilene Christian University, Abilene, Texas. Our collaborations involve the enzymes of the mevalonate pathway of the bacterial pathogen Enterococcus faecalis: HMG-CoA synthase, HMG-CoA reductase, mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate kinase decarboxylase, and isopentenyl diphosphate isomerase. Our interests encompass the solution of 3-D structures by X-ray crystallography, the identification of aminoacyl residues that function in catalysis, substrate and inhibitor recognition, or control of enzyme activity, and their application to the possible development of a new class of antiobiotics.
Selected Publications:
- Steussy, C. N., A. D. Robison, A. M. Tetrick, J. T. Knight, V. W. Rodwell, C. V. Stauffacher, and A. L. Sutherlin. A structural limitation on enzyme activity: The case of HMG-CoA synthase. Biochemistry 45:14407-14414 (2006).
- Steussy CN, Varia AA, Burgner JW II, Sutherlin A, Rodwell VW and Stauffacher CV. X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA. Biochemistry 44:14256-14267 (2005).
- Doun SS, Burgner JW II, Briggs SD, and Rodwell VW. Enterococcus faecalis phosphomevalonate kinase. Protein Science 14:1134-1139 (2005).
- Friesen JA and Rodwell VW. The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Genome Biol. 5:248-252 (2004).
- Sutherlin A and Rodwell VW. Multienzyme mevalonate pathway bioreactor. Biotech. Bioeng. 87:546-551 (2004).
- Hedl M and Rodwell VW. Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. Protein Science 13:1693-1697 (2004).
- Hedl M, Tabernero L, Stauffacher CV, and Rodwell VW. Class II HMG-CoA reductases. J. Bacteriol. 186:1927-1932 (2004).
- Hedl M and Rodwell VW. Enterococcus faecalis mevalonate kinase. Protein Science 13:687-693 (2004).
- Tabernero L, Rodwell VW and Stauffacher CV. Crystal structure of a statin bound to a class II HMG-CoA reductase. J. Biol. Chem. 278:19933-19938 (2003).
- Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW, Lehnbeuter KR, Stauffacher CV, Gwynn MN and Rodwell VW. Enterococcus faecalis acetoacetyl-CoA thiolase/HMG-CoA reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. J. Bacteriol. 184:2116-2122 (2002).
